AGE-DEPENDENT DOSE-RESPONSE RELATIONSHIP OF ORG NC45 IN ANAESTHETIZED PATIENTS

Abstract

The effects of age on the dose of Org NC45 [2.beta., 16.beta.-dipiperidino-5-androstane-3,17.beta.-diolacetate monomethobromide] were studied in 24 healthy, anesthetized patients using an on-demand infusion of the drug which produced a stable twitch height of 10% of its initial value. The patients were allocated as follows: group 1 = age < 40 yr; group 2 = 40-60 yr and group 3 = age > 60 yr. A steady-state dose measured every 10 min, was achieved in all the patients 30 min after the start of the administration of Org NC45. Significant decreases of steady-state dosage requirement (P = 0.01) and rate of recovery from blockade (P < 0.01) were observed between group 3 and the other 2 groups.