The Absorption, Excretion and Toxicity of Streptomycin in Man

Abstract

IN JANUARY, 1944, Schatz, Bugie and Waksman¹ described the isolation of a new antibacterial substance from the culture filtrate of Actinomyces griseus. They named this substance "streptomycin" and reported that it had a marked antibacterial action in vitro against many gram-negative and gram-positive bacteria. According to its discoverers, streptomycin resembled streptothricin, another antibacterial agent isolated in 1942,² but had a wider bacteriostatic spectrum and was quantitatively more active against certain organisms and less toxic for animals.Several studies^{3 4 5 6 7 8 9} have now been reported in which it has been shown that streptomycin is sufficiently effective in vivo in the treatment of experimental . . .