Effect of combined or separate administration of piracetam and choline on learning and memory in the rat
- 1 May 1987
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 92 (1), 58-67
- https://doi.org/10.1007/bf00215480
Abstract
Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect. Moreover, rats receiving P2C1 and P4C1 were significantly inferior in acquiring DA to rats receiving the vehicle or separate administration of P1, P2 or C1. The different treatments with combined or separate administration of P and C had no effect on spontaneous locomotor activity and two-way avoidance conditioning. In a recognition-task only groups C1 and P4 were able to discriminate between familiar and new objects. The combined or separate administration of P1 and C1 on NA, DA, DOPAC, 5-HT, 5-HIAA levels, CAT activity and choline uptake were measured in frontal cortex and hippocampus: the only significant effect was a 5-HT increase in the hippocampus of rats treated with C1.This publication has 72 references indexed in Scilit:
- Two-way avoidance and acute shock stress induced alterations of regional noradrenergic, dopaminergic and serotonergic activity in roman high- and low-avoidance ratsLife Sciences, 1983
- Cholinergic modulations and learningBehavioural Brain Research, 1983
- Visual recognition impairment following medial thalamic lesions in monkeysNeuropsychologia, 1983
- Effect of specific serotonergic lesions on cholinergic neurons in the hippocampus, cortex and striatumLife Sciences, 1983
- Piracetam in the treatment of cognitive impairment in the elderlyDrug Development Research, 1982
- Clinical Response to Choline plus Piracetam in Senile Dementia: Relation to Red-Cell Choline LevelsNew England Journal of Medicine, 1981
- Mortality in Cigarette Smokers and QuittersNew England Journal of Medicine, 1981
- Piracetam diminishes hippocampal acetylcholine levels in ratsLife Sciences, 1981
- Role of temporal lobe structures in visual short-term memory, using a new testNeuropsychologia, 1977
- Nootropic drugsProgress in Neuro-Psychopharmacology, 1977