Amino‐acids condensations in the preparation of Nα‐9‐fluorenylrnethyloxycarbonylamino‐acids with 9‐fluorenylmethylchloroformate
- 1 July 1983
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 22 (1), 125-128
- https://doi.org/10.1111/j.1399-3011.1983.tb02076.x
Abstract
Synthesis of N alpha-9-fluorenylmethyloxycarbonyl (Fmoc) amino-acids by reaction of free amino-acids (glycine and alanine) with 9-fluorenylmethylchloroformate leads to formation of small amounts of Fmoc-dipeptide which are difficult to eliminate by crystallization. The alternative way to prepare Fmoc-amino-acids by reacting the Fmoc-chloride first with sodium azide and then with the free amino-acid eliminates this side reaction, at least for glycine and alanine.Keywords
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