Alterations in the size of the poly(a) segment in newly-synthesized messenger RNA of mouse sarcoma 180 ascites cells
- 1 June 1973
- journal article
- Published by Springer Science and Business Media LLC in Molecular Biology Reports
- Vol. 1 (1), 7-13
- https://doi.org/10.1007/bf00357399
Abstract
The size of the poly(A) segment present at the 3′-end of mRNA molecules decreases gradually after entry of the mRNA into the cytoplasm. The size reduction seems to occur equally in free and polysome-bound mRNA. It is not affected by conditions that inhibit protein synthesis, such as treatment with cycloheximide and amino acid deprivation. The latter condition leads to a substantial increase in the size of nuclear poly(A). The rate of poly(A) cleavage could determine the length of time a mRNA molecule remains functional in the cytoplasm.Keywords
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