Microbial Synergism in Human Infections

Abstract

KOCH'S postulates may not always apply to human infections. In fact, many mixed infections appear to be synergistic processes in which disease exists only if each of a minimum number of different micro-organisms are present. Some infections may even be treated successfully with agents that are only active against a segment of the total microbial population. Microbial synergism may involve any of four basic types of interactions. Micro-organisms can lower the resistance of the host and in so doing increase the likelihood of invasion by another micro-organism. They may also facilitate colonization of potential hosts, provide elements that are essential . . .