The Physiological Disposition of Ibuterol, Terbutaline and Isoproterenol after Endotracheal Instillation to Rats
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (9), 521-529
- https://doi.org/10.3109/00498257509056122
Abstract
1. The absorption from the respiratory tract and biotransformation of three bronchodilating drugs, terbutaline, ibuterol (diisobutyrate ester of terbutaline) and isoproterenol, have been studied in rats after endotracheal instillation. 2. At 2-15 min after dosage, ibuterol is more rapidly absorbed from the respiratory tract than terbutaline, but later (15-35 min), absorption of ibuterol is about the same as terbutaline. Absorption of isoproterenol is rapid throughout the experiment. Absorption rates have been related to the physical-chemical properties of the compounds. 3. No significant biotransformation of terbutaline was noted in the rat lung at any time after dosage, but ibuterol is extensively hydrolysed to terbutaline. Extensive biotransformation of isoproterenol to 3-methoxy-isoproterenol and an unidentified metabolite occurred. Metabolites of terbutaline and isoproterenol were found in serum and liver.Keywords
This publication has 15 references indexed in Scilit:
- Phenol red absorption from the rat lung: Evidence of carrier transportLife Sciences, 1973
- The Metabolism of Sympathomimetic Bronchodilator Drugs by the Isolated Perfused Dog LungXenobiotica, 1973
- The Metabolism of Terbutaline in Dog and RatXenobiotica, 1973
- The Effect of Route of Administration on the Metabolic Fate of Terbutaline in the RatXenobiotica, 1973
- The Tissue Distribution of3H-Terbutaline (Bricanyl®) in MiceActa Physiologica Scandinavica, 1972
- The Metabolism of TerbutalineIn Vitroby Rat and Human LiverO-Methyltransferases and Monoamine OxidasesXenobiotica, 1972
- The Distribution, Elimination, and Biotransformation of 14C‐Cloforex in the Mouse and RatActa Pharmacologica et Toxicologica, 1970
- Absorption and Elimination Profile of Isoproterenol IIIJournal of Pharmaceutical Sciences, 1968
- Autoradiographic Distribution Studies of Adrenergic Blocking Agents. II. 14C‐Propranolol, a β‐Receptor‐Type BlockerActa Pharmacologica et Toxicologica, 1967
- Tissue Levels of Chloroamphetamines in Rats and MiceJournal of Pharmaceutical Sciences, 1967