THE INFLUENCE OF DUODENAL SECRETIONS ON ACID GASTRIC CONTENTS

Abstract

In 2 dogs after pyloroplasty there was no evidence that more duodenal secretions entered the stomach than before. In 2 dogs after gastroduodenof-tomy and in 2 after gastrojejunostomy, large amts. of duodenal secretions entered the stomach. The av. total amt. of duodenal secretions in the samples removed from the stomach after operation was 75 cc. per 1/2 hr. and occasionally exceeded 100 cc. in individual exps. The av. composition of the duodenal secretions was the same as that previously found, the av. alkalinity being ca. 0.04 N while the av. chloride conc. was 320 mgm. %. The efficiency of duodenal secretions in lowering the acidity of ca. N/10 HCl in the stomach is due more to dilution than to neutralization; on the average, 75% of the reduction in acidity was due to dilution and 25% to neutralization. The presence in it of large amts. of duodenal secretions seems to cause a hypersecretiqn of acid by the histamine-stimulated (but not the unstimulated) stomach. The chloride concn. of the mixed gastric secretions depends on the relative amts. of acid fluid and extra fluid present.