COAMPLIFICATION OF THE hst‐1 AND int‐2 GENES IN HUMAM CANCERS
- 1 April 1988
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 79 (4), 428-432
- https://doi.org/10.1111/j.1349-7006.1988.tb01609.x
Abstract
The hst-1 gene, previously designated the hst gene, was identified as a transforming gene by transfection assays of genomic DNAs from various types of human cancers. We analyzed for alterations of the hst-1 gene in 18 bladder cancers, 23 renal cell carcinomas and 5 esophageal cancers. Although rearrangement of the gene was not detected in any of these samples, amplification of the hst-1 gene was found in 4 samples of tumors, including an invasive bladder cancer, both primary esophageal cancer and its lymph node metastasis, and kidney metastasis of an esophageal cancer. The same degree of amplification of the int-2 gene, the product of which has significant homology with the hst-1-encoded protein, was also observed in all of these DNA samples with amplified hst-1 gene. This result indicates close chromosomal localization of the two genes, which were amplified as one amplification unit.Keywords
This publication has 26 references indexed in Scilit:
- Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.Proceedings of the National Academy of Sciences, 1987
- An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF familyCell, 1987
- Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA.Proceedings of the National Academy of Sciences, 1987
- The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.Proceedings of the National Academy of Sciences, 1987
- Mesoderm induction in early Xenopus embryos by heparin-binding growth factorsNature, 1987
- Genomic clone of hst with transforming activity from a patient with acute leukemiaBiochemical and Biophysical Research Communications, 1987
- Complete primary structure of prostatropin, a prostate epithelial cell growth factorBiochemistry, 1986
- Alterations of myc , myb , and ras Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical CorrelationScience, 1986
- Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumorsCell, 1983
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975