Observations on Induced Caries in Rats
- 1 February 1948
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 27 (1), 34-40
- https://doi.org/10.1177/00220345480270010701
Abstract
The inhibitory effects of fluorine on induced rat caries are apparent at a level of 10 ppm in drinking water and are independent of any association with Na2SO4, MgCl2, or free I in the water. Urea inhibited rat caries to a limited extent, when given in somewhat excessive quantities in the food and water. Nitrate added to the drinking water and food seemed consistently to inhibit exptl. rat caries. Penicillin and iodoacetate have been reported from previous studies as markedly caries-inhibitory. The following substances gave no indication of any pronounced effect on induced rat caries; Fe, Cu, Zn, CaCl, Na2SO4, MgCl2, KI, free I, K thiocyanate, and a strongly alkaline drinking fluid.Keywords
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