Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipase
- 15 April 1980
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 188 (1), 185-192
- https://doi.org/10.1042/bj1880185
Abstract
The lipoprotein lipase activity of epididymal fat-bodies from starved rats was measured during incubations at 37.degree. C in vitro. Protein-synthesis-independent activation of the enzyme, previously observed during incubations at 25.degree. C, also occurs at 37.degree. C. Protein-synthesis-dependent increased in the activity of the enzyme occur in the presence of insulin and are markedly potentiated by glucocorticoids. The effects on the enzyme activity of insulin alone, or in the presence of glucocorticoids, are correlated with its effects on total protein synthesis in the tissue. Adrenaline [epinephrine] antagonizes the increase in enzyme activity brought about by insulin and abolishes the potentiation of insulin action by glucocorticoids. These changes may be due, at least in part, to its stimulation of inactivation of the enzyme in the tissue. Changes in adipose-tissue lipoprotein lipase activity that occur with changes in nutritional status in vivo apparently result from the combined effects of changes in plasma insulin and glucocorticoid concentrations.This publication has 24 references indexed in Scilit:
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