Prophenin‐1, an exceptionally proline‐rich antimicrobial peptide from porcine leukocytes
- 27 March 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 362 (1), 65-69
- https://doi.org/10.1016/0014-5793(95)00210-z
Abstract
We purified and characterized an unusual antimicrobial peptide, prophenin-1 (PF-1), from porcine leukocytes. The peptide had a mass of 8,683 and contained 79 residues, including 42 (53.2%) prolines and 15 (19.0%) phenylalanines. Its N-terminal 60 residues consisted of three perfect and three nearly perfect repeats of a decamer, FPPPNFPGPR. Prophenin-1 was encoded on a cathelin-containing precursor and showed substantially more activity against E. coli, a Gram-negative bacterium, than against Listeria monocytogenes, a Gram-positive organism, in vitroKeywords
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