AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii
Open Access
- 1 February 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (2), 791-793
- https://doi.org/10.1128/aac.49.2.791-793.2005
Abstract
Transposon mutagenesis of a clinical isolate of Morganella morganii , G1492 (tigecycline MIC of 4 μg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 μg/ml. Transposon insertions mapped to acrA , which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii .Keywords
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