Tc‐99m markierte Östradiol‐derivate synthese, organverteilung und tumor‐affinität

Abstract

As starting material for the Tc‐99m labelling 17‐(Ferrocenyl‐ethinyl)‐estradiol and 16‐(Ferrocenyliden)‐estron were synthesized.These ferrocene derivatives were heated with Mn‐Br(CO)₅ and Tc‐99m‐pertechentate to yield the labelled corresponding cytectrene steroid compounds. In organ distribution studies with infantile female rats a binding of the Tc‐99m labelled steroids to the estradiol receptor in the rat uterus was demonstrated. The binding to MXT‐mamma tumors in mice yielded a Tc‐99m concentration ratio tumor/muscle of 3:1.