Studies on the tumor‐promoting activity of biomaterials: Inhibition of metabolic cooperation by polyetherurethane and silicone
- 1 January 1995
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 29 (1), 113-119
- https://doi.org/10.1002/jbm.820290116
Abstract
When V79 metabolic cooperation (MC) assay was performed to detect tumor‐promoting activities, inhibitory activities on the gap‐junctional intercellular communication were first detected in both extracts prepared from polyetherurethane (PEU) and silicone. The former inhibited more strongly than the latter. Furthermore, the lowest effective concentrations in MC assay correlated well with the values of the total active incidences obtained by histologic evaluation of the 2‐year implantation test in rats. Poly(tetramethylene oxide) (PTMO) showed the highest inhibitory activities among the constituents of PU. Thus, the shorter the chain length of PTMO, the stronger the inhibitory activities of PTMO in MC assay. PTMO moiety may play an important role in the tumor‐promotion stage during tumorigenesis induced by PU. © 1995 John Wiley & Sons, Inc.This publication has 9 references indexed in Scilit:
- Degradation of polyetherurethane by subcutaneous implantation into rats. I. Molecular weight change and surface morphologyJournal of Biomedical Materials Research, 1994
- Difference in tumor incidence and other tissue responses to polyetherurethanes and polydimethylsiloxane in long‐term subcutaneous implantation into ratsJournal of Biomedical Materials Research, 1992
- Effect of soft segment chemistry on the biostability of segmented polyurethanes. I. In vitro oxidationJournal of Biomedical Materials Research, 1991
- Foreign‐body giant cells and polyurethane biostability: In vivo correlation of cell adhesion and surface crackingJournal of Biomedical Materials Research, 1991
- Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents.Environmental Health Perspectives, 1986
- Genetic damage in CHO cells exposed to enzymically generated active oxygen speciesMutation Research, 1984
- Foreign-body tumorigenesis in rats by various kinds of plastics - Induction of malignant fibrous histiocytomas.The Journal of Toxicological Sciences, 1984
- Elimination of Metabolic Cooperation in Chinese Hamster Cells by a Tumor PromoterScience, 1979
- Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cellsBiochemical and Biophysical Research Communications, 1979