Elimination of Metabolic Cooperation in Chinese Hamster Cells by a Tumor Promoter
- 30 November 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 206 (4422), 1089-1091
- https://doi.org/10.1126/science.493994
Abstract
Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.Keywords
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