Ranitidine, 150 mg Three Times a Day, in the Treatment of Reflux Oesophagitis: A Placebo-Controlled, Double-Blind Study

Abstract

The effect of ranitidine, 150 mg three times a day, in the treatment of reflux oesophagitis was studied. A double-blind method was used, and 41 patients with endoscopically verified symptomatic oesophagitis were randomly allocated to ranitidine or placebo. In addition, antacid tablets could be taken as needed. Eighteen patients in both the ranitidine and the placebo groups completed the study. Endoscopically, the healing rate was significantly higher in the ranitidine group after both 6 weeks' (p < 0.05) and 12 weeks' (p < 0.01) treatment. The proportion of patients whose oesophagitis healed or improved was also higher in the ranitidine group (p < 0.05). The patients receiving ranitidine used significantly (p < 0.002) less antacids than the controls, suggesting a favourable effect of ranitidine on the symptoms of oesophagitis. The histological study did not show significant differences between the ranitidine and the placebo groups. No serious side effects were noted. Ranitidine in a dose of 150 mg three times a day is effective and safe in the treatment of reflux oesophagitis.