A Fluorescent Nanosensor for Apoptotic Cells
- 3 February 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 6 (3), 488-490
- https://doi.org/10.1021/nl0524694
Abstract
A biocompatible surface-functionalized nanoparticle was designed to sense phosphatidylserine exposed on apoptotic cells. We conjugated synthetic artificial phosphatidylserine binding ligands in a multivalent fashion onto magnetofluorescent nanoparticles. Our results show that (1) the synthetic nanoparticles bind to apoptotic cells, (2) there is excellent correlation with annexin V staining by microscopy, and (3) FACS analysis with nanoparticles allows the measurement of therapeutic apoptosis induction. The described nanomaterials should be useful for a variety of biomedical applications including in vivo imaging of apoptosis.Keywords
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