Timed-Disintegration Capsules (Tymcaps) — A Further Study

Abstract

WE have continued our study of timed-disintegration capsules to amplify the description of the disintegration pattern and to compare the x-ray visualization of the breakdown of the capsules with blood-level determinations by pentaerythritol tetranitrate.LiteratureBefore publication of the in vivo roentgenographic study¹ little could be found in the literature relating to timed-disintegration capsules. According to a study by the Pharmaceutical Chemical, Vitamin and Nutrition Sections of the Canadian Department of National Health and Welfare,² a nonmetabolite (sodium para-aminosalicylate) is less available the longer the in vivo disintegration time. The original work by the same group had been criticized by . . .