Methysergide-induced heart disease: a case of multivalvular and myocardial fibrosis.

Abstract

Methysergide (Sansert), an anti-serotonin agent used for prophylaxis of migraine headaches, is known to cause mitral and aortic valvular fibrosis and dysfunction but genrally were not known to damage right heart valves or the myocardium and cardiac fibrosis was not considered to be a risk if therapy was intermittently interrupted. A case report of a woman who developed catherterization-proven severe tricuspid and moderate aortic and mitral regurgitation during noncontinuous therapy with methysergide is presented. Right ventricular endomyocardial biopsy revealed extensive endocardial and intramyocardial fibrosis.