A Kinetic Study On Murine Myeloid Leukaemia

Abstract

A kinetic study was made on murine myeloid leukaemia, using the myeloid leukaemia colony in the spleen as a model system. The number of myeloid leukaemia colony-forming units (MLCFU) recoverable from the bone marrow, spleen and liver increased exponentially as a function of time from day 1 up to day 9, after the initial lag period of 12-24 hours. The f-values were estimated to be about 67 per cent in the above 3 organs. After day 10, the number of MLCFU declined in these organs. The myeloid leukaemia was sensitive to cyclophosphamide and chlorambucil, as determined by the slopes of the survival curves obtained for MLCFU. Finally, an entity of the mixed type in the myeloid leukaemia colony was described.