Association of distinct clinical subsets with myositis‐specific autoantibodies towards anti‐155/140‐kDa polypeptides, anti‐140‐kDa polypeptides, and anti‐aminoacyl tRNA synthetases in Japanese patients with dermatomyositis: a single‐centre, cross‐sectional study
- 1 January 2009
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 38 (4), 263-267
- https://doi.org/10.1080/03009740802687455
Abstract
To determine the association of distinct clinical subsets with myositis-specific autoantibodies (MSAs) towards anti-155/140-kDa polypeptides [anti-155/140 antibodies (Abs)], anti-140-kDa polypeptides (anti-140 Abs), and anti-aminoacyl tRNA synthetases (ARS Abs) in Japanese patients with dermatomyositis (DM). We compared the clinical features and short-term prognoses of 30 DM patients whose serological status included these MSAs. The MSAs were determined by immunoprecipitation. Anti-155/140 Abs (n = 5), anti-140 Abs (n = 8), and anti-ARS Abs (n = 7) did not overlap each other. All of the anti-155/140 Ab-positive patients (n = 5) were complicated by malignancies, as were all of the anti-140 Ab-positive patients (n = 8), who showed rapidly progressive interstitial lung disease (ILD). The survival rate at 6 months from the diagnosis of DM was significantly lower in the anti-140 Ab-positive patients than in the other patients. This is the first study to report, in a single cohort of DM patients, that distinct clinical subsets are distributed in an anti-155/140 Ab-positive group, an anti-140 Ab-positive group, or an anti-ARS Ab-positive group. Our data also confirm previous evidence that anti-155/140 Abs are involved in malignancies and that anti-140 Abs are involved in rapidly progressive ILD.Keywords
This publication has 11 references indexed in Scilit:
- Functional and morphological evaluation of hand microcirculation with nailfold capillaroscopy and laser Doppler imaging in Raynaud's and Sjögren's syndrome and poly/dermatomyositisScandinavian Journal of Rheumatology, 2008
- Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significanceCurrent Opinion in Rheumatology, 2007
- Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomesArthritis Research & Therapy, 2007
- A novel autoantibody to a 155‐kd protein is associated with dermatomyositisArthritis & Rheumatism, 2006
- Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancyRheumatology, 2006
- A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis siné myositis): A missing link within the spectrum of the idiopathic inflammatory myopathiesJournal of the American Academy of Dermatology, 2006
- Autoantibodies to a 140‐kd polypeptide, CADM‐140, in Japanese patients with clinically amyopathic dermatomyositisArthritis & Rheumatism, 2005
- Dermatomyositis: an overview of recent progress with emphasis on dermatologic aspectsDermatologic Clinics, 2002
- Polymyositis and DermatomyositisNew England Journal of Medicine, 1975
- Polymyositis and DermatomyositisNew England Journal of Medicine, 1975