The fate of certain organic acids and amides in the rabbit

Abstract

The metabolism of benzoic and phenylacetic acids and their amides was studied by detn. of the increased excretion of ether-soluble acid and reducing substances. The % of dose of benzoic acid excreted (in 24 hrs.) conjugated with glycine was 77 and that with glucuronic acid was 11. Corresponding values for benzamide were 76 and 4; for phenylacetic acid, 53 and 5; and for phenylacetamide, 55 and 4. No increase in ethereal sulphate was observed.