Nasal Decongestant Activity of Pseudoephedrine
- 1 March 1977
- journal article
- research article
- Published by SAGE Publications in Annals of Otology, Rhinology & Laryngology
- Vol. 86 (2), 235-242
- https://doi.org/10.1177/000348947708600216
Abstract
The effectiveness of orally administered pseudoephedrine in patients with acute or chronic nonsuppurative rhinitis was evaluated under double-blind conditions. Intranasally administered ephedrine which was given to all patients at the end of this study served as the positive control. Marked nasal decongestant effects of a single oral dose of pseudoephedrine (60 mg tablet), as determined by a modified passive anterior, rhinometrie technique occurred within 30 minutes and were maintained for at least four hours. The mean nasal decongestant response (Δ% of baseline) of 57.2% was associated with a mean peak, plasma pseudoephedrine level of 274 ng/ml. In addition, the maximum response to oral pseudoephedrine treatment was equivalent to the response produced by ephedrine nasal spray. These results suggest that pseudoephedrine is an orally effective nasal decongestant.Keywords
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