Histamine may act through cyclic AMP on hippocampal neurones
- 1 April 1985
- journal article
- histamine in-the-central-nervous-system
- Published by Springer Nature in Inflammation Research
- Vol. 16 (3-4), 234-235
- https://doi.org/10.1007/bf01983148
Abstract
Bath applied histamine and 8-bromo-cyclic AMP and intracellularly injected cyclic AMP block-long-lasting afterhyperpolarizations and the accommodation of firing in CA1 pyramidal cells recorded in rat hippocampal slices. This action is due to reduction of a calcium-activated potassium conductance (gK(Ca)) and leads to potentiation of excitatory signals including epileptiform discharges. The effects are further potentiated and prolonged by a phosphodiesterase inhibitor (Ro 20-1724).Keywords
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