Action of Insulin on Distribution of Glucose Analogs in Eviscerated-Nephrectomized Dogs

Abstract

Insulin increased the distribution of 2-deoxyglucose, 3-deoxyglucose and 2-deoxygalactose in eviscerated-nephrectomized dogs. 6-O-methylglucose was nonresponsive to insulin. The response of 3-O-methylglucose appeared dependent upon the blood glucose level. These results are interpreted as indicating that the stereochemical requirements of aldohexoses for insulin response does not require a hydroxyl group on either carbon 2 or 3 of the molecule, nor does it require a specific configuration of the hydroxyl on carbon 4. It is suggested from the behavior of the methylated analogs that the size rather than the functional nature of the group at carbons 3 and 6 is important in determining insulin responsiveness.