2-Deoxyglucose--A Metabolic Block for Glucose.

Abstract

2-Deoxyglucose was given to control and insulin treated eviscerated nephrecto-mized rabbits. It was found that 2-deoxyglucose rapidly enters the cells of the extrahepatic tissues in the absence of insulin. Insulin appears to accelerate the intracellular transfer. The intracellular transfer of 2-deoxyglucose inhibits the transfer and oxidation rates of glucose, thus acting as a metabolic block for glucose. It is suggested that the blocking of glucose may take place at the 6-phosphate stage.