Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 312 (5994), 517-520
- https://doi.org/10.1038/312517a0
Abstract
Hybridomas were produced from spleen cells of .kappa. transgenic mice to investigate expression of the transgenic .kappa. gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. The transgene is expressed normally and the production of a complete Ig molecule turns off light-chain gene rearrangement.Keywords
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