Müllerian adenosarcoma of the uterine cervix with heterologous elements.A light and electron microscopic study
- 1 April 1976
- Vol. 37 (4), 1725-1736
- https://doi.org/10.1002/1097-0142(197604)37:4<1725::aid-cncr2820370418>3.0.co;2-1
Abstract
A müllerian adenosarcoma with heterologous elements having the gross appearance of a sarcoma botryoides occurred in the uterine cervix of a 14-year-old girl. Histologically, the tumor was composed of an admixture of benign-appearing glands and a sarcomatous stroma, the latter containing areas of undifferentiated sarcoma and endometrial stromal sarcoma, as well as heterologous elements consisting of rhabdomyosarcoma and hyaline cartilage. No malignant epithelial component was observed. The distribution of benign müllerian-type glands throughout the tumor simulated a malignant mixed müllerian tumor in appearance. Ultrastructural studies of the stromal elements of the neoplasm suggest origin from primitive müllerian stroma, and the glands have features of primitive müllerian epithelium. This study supports the concept that the malignant mixed müllerian tumor and related müllerian sarcomas originate from a common undifferentiated multipotential müllerian stem cell.Keywords
This publication has 27 references indexed in Scilit:
- Papillary Adenofibroma of the Uterus: A Benign Mesodermal Mixed Tumor of Müllerian OriginAmerican Journal of Clinical Pathology, 1973
- Papillary adenofibroma of the uterine cervixAmerican Journal of Obstetrics and Gynecology, 1971
- Malignant mixed mesodermal tumor of the uterus: An ultrastructural studyAmerican Journal of Obstetrics and Gynecology, 1971
- Uterine sarcomasHuman Pathology, 1970
- Mesenchymal sarcoma of the cervix uteri: case reportPathology, 1969
- Ultrastructure of the human endometrial stroma cell during the menstrual cycleAmerican Journal of Obstetrics and Gynecology, 1968
- Sarcoma Botryoides of the CervixObstetrics & Gynecology, 1968
- AN ELECTRON MICROSCOPE STUDY OF MYOFIBRIL FORMATION IN EMBRYONIC CHICK SKELETAL MUSCLEThe Journal of cell biology, 1967
- Carcinosarcoma (Malignant Mixed Mesodermal Tumor) of the UterusAmerican Journal of Clinical Pathology, 1963
- Malignant mixed Müllerian neoplasms (mixed mesodermal tumors)American Journal of Obstetrics and Gynecology, 1961