EFFECTS OF DEOXYRIBONUCLEIC ACID PRODUCTS ON DEOXYRIBONUCLEIC ACID SYNTHESIS OF VIRULENT AND AVIRULENT PNEUMOCOCCI
- 1 August 1961
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 82 (2), 169-+
- https://doi.org/10.1128/jb.82.2.169-180.1961
Abstract
Cell suspensions of virulent pneumococci synthesize a greater amount of deoxyribonucleic acid (DNA) per cell in the presence of DNA + deoxyribonuclease + mixtures of deoxynucleosides and deoxy-nucleotides (supplement-1) thanunsupplemented suspensions. Under identical conditions, avirulent and weakly virulent pneumococci do not respond to these DNA breakdown products. Glucose and casitone must be present for maximal effects to occur. A DNA turnover occurs in virulent cells. This has been demonstrated by a decrease in specific activity of H3-DNA extracted from virulent (S) cells exposed to nonradioactive supplement-1.Keywords
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