Internalization of ionotropic glutamate receptors in response to mGluR activation
- 22 October 2001
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (11), 1079-1085
- https://doi.org/10.1038/nn746
Abstract
Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.Keywords
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