In Vitro Lymphocyte Response of Patients with Immunologic Deficiency Diseases

Abstract

Patients with congenital thymic aplasia are unable to manifest delayed hypersensitivity in vivo and in vitro, but usually possess normal levels of immunoglobulins. Patients with X-linked agammaglobulinemia, however, exhibit normal delayed hypersensitivity in vivo, but in vitro studies of lymphocyte transformation have been conflicting.