Demonstration of T15 idiotype‐positive effector and suppressor T cells for phosphorylcholine‐specific delayed‐type hypersensitivity response in CBA/N or (CBA/N X BALB/c)F1 male mice
- 1 January 1981
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 11 (6), 455-461
- https://doi.org/10.1002/eji.1830110604
Abstract
Subcutaneous immunization of CBA/N or (CBA/N x BALB/c)F1 (NBF1) male mice, which were defective in phosphorylcholine (PC)‐specific humoral antibody response, with PC‐conjugated syngeneic spleen cells induced a PC‐specific delayed‐type hypersensitivity (DTH) response, while intravenous administration of the same cells induced PC‐specific suppressor T cells for the DTH response. Treatment of PC‐specific effector or suppressor T cells for the DTH response induced in NBF1 male mice with anti‐T15 idiotypic antibody inactivated effector or suppressor functions of these T cells implying that PC‐specific T cells in NBF1 mice expressed T15 idiotypic determinants on their surface. Enrichment of PC‐specific suppressor T cells was also shown by employing anti‐T15 antibody‐coated dishes.This publication has 31 references indexed in Scilit:
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