THE ESTIMATION OF RENAL FUNCTION IN THE RAT BY THE USE OF DIODRAST AND INULIN

Abstract

The detn. of renal function by clearance methods is applied to the rat. The method described prepares the rat for a clearance period by timed subcut. injs. of diodrast and inulin in amts. calculated to yield specific plasma levels. A urine collection period of 1 hr. follows, during which the urethra is tied off. Plasma values are based on those found in a blood sample taken in the mid-collection period. The data indicated that in the normal [male] rat, inulin plasma clearance averaged 0.0027 cc./g. of body wt./min., diodrast plasma clearance 4 averaged 0.0133 cc./g./min., while TmD averaged 0.00142 mg./g./min. The avg. Filtration Fraction value is 20.02%.