Influence of Muscular Exercise on Uric Acid Excretion in Man

Abstract

Exercise, even of short duration and moderate severity, results in a depression of uric acid clearance to values as low as 20-30% of the pre-exercise values. The clearance remains depressed for at least 1 hr. following exercise. The decrease in urate clearance is proportional to the decrease in filtration rate during the exercise period, but urate clearance returns to normal much more slowly than does filtration rate during the recovery period, indicating an increase in tubular reabsorption. The altered tubular reabsorption of uric acid is correlated with the rise in blood lactate associated with exercise and is greatly diminished when exercise is unaccompanied by hyperlactacidemia. The oral admn. of buffered Na lactate results in a similar depression of uric acid clearance, so that the lactate effect is apparently not dependent on the production of systemic acidosis.