TRH by slow, continuous infusion: an antidepressant?
- 1 August 1976
- journal article
- clinical trial
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 6 (3), 393-397
- https://doi.org/10.1017/s0033291700015828
Abstract
Synopsis: A slow, continuous infusion of 1000μg TRH (thyrotropin releasing hormone) over a period of 4 h had a very faint and diffuse short-lasting beneficial effect on a group of 10 depressive patients. This was assessed in a double blind cross-over trial with placebo. The effect was of no therapeutic value. No difference was found between the depressive patients and a control group of normal subjects in TSH response, T3resin uptake, T4or free thyroxine index values as a consequence of the TRH infusion.Keywords
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