Nucleolus organizer activity and the origin of Robertsonian translocations
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 20 (1-6), 40-50
- https://doi.org/10.1159/000130838
Abstract
Chromosomes with active nucleolus organizer regions (NORs) were identified by combined Q-banding, C-banding (in some cases), and silver staining in mouse cell lines. NOR-bearing chromosomes were overrepresented among the chromosomes involved in Robertsonian translocations in LM(TK-), A9, and RAG cell lines. Usually only one NOR-bearing chromosome was seen in any biarmed chromosome; relatively few contained two NOR-bearing chromosomes. Thus the nucleolus plays an important role, but nucleolar fusion is relatively unimportant, in the origin of Robertsonian translocations in the mouse.Keywords
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