Anti‐cAngptl4 Ab‐Conjugated N‐TiO2/NaYF4:Yb,Tm Nanocomposite for Near Infrared‐Triggered Drug Release and Enhanced Targeted Cancer Cell Ablation
- 4 June 2012
- journal article
- research article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 1 (4), 470-474
- https://doi.org/10.1002/adhm.201200055
Abstract
Nanomedicine: NIR-active N-TiO2/NaYF4:Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm NCs shows a significant increase in apoptotic A-5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR-induced photocatalysis, drug release and targeted cancer cell killing are proposed.This publication has 26 references indexed in Scilit:
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