Synthesis and Molecular Recognition of Phosphatidylinositol-3-methylenephosphate
- 24 May 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (13), 2811-2813
- https://doi.org/10.1021/ol060903i
Abstract
Phosphatidylinositol-3-phosphate (PtdIns(3)P) is a spatial regulator of vesicular trafficking and other vital cellular processes. We describe the asymmetric total synthesis of a metabolically stabilized analogue, phosphatidylinositol-3-methylenephosphate (PtdIns(3)MP) from a differentially protected myo-inositol. NMR studies of PtdIns(3)MP bound to the 15N-labeled FYVE domain showed significant 1H and 15N chemical shift changes relative to the unliganded protein.Keywords
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