Ovarian function after successful bone marrow transplantation in postmenarcheal females
- 1 January 1983
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 11 (5), 361-364
- https://doi.org/10.1002/mpo.2950110514
Abstract
Ovarian function was followed serially in a group of six postmenarcheal females after successful bone marrow transplantation (BMT). The patients were between 13 9/12 and 22 6/12 (median 16 5/12) years of age at the time of BMT and were followed a median of 20 months (range 17‐45 months) posttransplantation. Two subjects received short‐term high‐dose cyclophosphamide combined with single‐dose total lymphoid irradiation (Group I), whereas the remaining four were treated with short‐term, high‐dose chemotherapy plus single‐dose total body irradiation (Group II). Group II subjects also received combination chemotherapy prior to BMT. One subject from Group I continues to have regular menses and normal gonadotropin levels, 36 months post‐BMT. The remaining five patients have demonstrated persistently elevated plasma concentrations of LH and FSH over a 17‐ to 45‐month period of time. None of the four patients in Group II has menstruated since undergoing BMT. We conclude that single‐dose radiation combined with short‐term, high‐dose chemotherapy results in profound ovarian damage in the majority of young women undergoing BMT.Keywords
This publication has 16 references indexed in Scilit:
- Some Cytokinetic and Histopathologic Considerations of Irradiated Male and Female Gonadal TissuesPublished by S. Karger AG ,2015
- Bone marrow transplantation for non-Hodgkin's lymphoma in children and young adultsAmerican Journal Of Medicine, 1983
- Female Reproductive Potential after Treatment for Hodgkin's DiseaseNew England Journal of Medicine, 1981
- Ovarian failure in long-term survivors of childhood malignancyAmerican Journal of Obstetrics and Gynecology, 1981
- Effects of cancer chemotherapy on gonadal function of patientsCancer Treatment Reviews, 1980
- Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemiaInternational Journal of Radiation Oncology*Biology*Physics, 1979
- Total-Body Irradiation with a High-Dose-Rate Linear Accelerator for Bone-Marrow Transplantation in Aplastic Anemia and Neoplastic DiseaseRadiology, 1977
- Ovarian failure following abdominal irradiation in childhoodBritish Journal of Cancer, 1976
- The effects of gonadal irradiation in clinical radiation therapy: A reviewCancer, 1976
- Radiosensitivity of mammalian oocytes with particular reference to the human femaleAmerican Journal of Obstetrics and Gynecology, 1971