FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk
- 1 May 2010
- journal article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 91 (5), 1368-1376
- https://doi.org/10.3945/ajcn.2009.28789
Abstract
Background: The genes encoding Δ5- and Δ6-desaturases (FADS1 FADS2 gene cluster) were reported to be associated with n−3 (omega-3) and n−6 (omega-6) fatty acid proportions in human plasma, tissues, and milk. Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from α-linolenic acid through a pathway involving these desaturases.Keywords
This publication has 32 references indexed in Scilit:
- Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactationProstaglandins, Leukotrienes & Essential Fatty Acids, 2009
- Dietary Arachidonic Acid Dose-Dependently Increases the Arachidonic Acid Concentration in Human MilkJournal of Nutrition, 2008
- Long-Chain Polyunsaturated Fatty Acids Influence the Immune System of Infants1,2,Journal of Nutrition, 2008
- Supplementation with 200 mg/Day Docosahexaenoic Acid from Mid-Pregnancy through Lactation Improves the Docosahexaenoic Acid Status of Mothers with a Habitually Low Fish Intake and of Their InfantsAnnals of Nutrition and Metabolism, 2008
- Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistanceDiabetologia, 2007
- Long-chain polyunsaturated fatty acids in maternal and infant nutritionProstaglandins, Leukotrienes & Essential Fatty Acids, 2006
- Distribution, interconversion, and dose response of n−3 fatty acids in humansThe American Journal of Clinical Nutrition, 2006
- The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retinaProgress in Lipid Research, 2001
- Cloning, Expression, and Fatty Acid Regulation of the Human Δ-5 DesaturaseJournal of Biological Chemistry, 1999
- Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 DesaturaseJournal of Biological Chemistry, 1999