A Steroid Response Element Can Function in the Absence of a Distal Promoter
- 30 November 1988
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 2 (12), 1286-1293
- https://doi.org/10.1210/mend-2-12-1286
Abstract
The glucocorticoid-progesterone responsive element (GRE/PRE) of the tyrosine aminotransferase (TAT) gene is a steroid-inducible enhancer. We show that the GRE/PRE can also work in the absence of a distal promoter element when located 5'' to the ovalbumin TATA box. The GRE/PRE in this position retains progesterone or glucocorticoid receptor and hormone dependency for the induction of gene expression. Initiation of transcription occurs correctly, and induction occurs at the mRNA level. These data indicate that a steroid-inducible enhancer can function without a distal promoter element.This publication has 14 references indexed in Scilit:
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