A CORRELATION BETWEEN THE STRUCTURE OF NEOMYCIN B AND ITS ACTION ON BACTERIA
- 1 February 1958
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 75 (2), 199-204
- https://doi.org/10.1128/jb.75.2.199-204.1958
Abstract
Growth-inhibitory effect of neomycin B, neomycin C and neamine on 24 bacterial species was investigated. Differences in such an effect were found in most of the organisms tested. They were particularly striking in 2 bacteria, Corvnebacterium sp. and Sarcina lutea. Growth of Corvnebacterium was inhibited by approximately 250 [mu]g of neamine or neomycin C per ml but by only 0.4 to 1.6 [mu]g of neomycin B per ml. The inhibitory concentrations of neomycin B remained practically unchanged when neomycin C and neamine were added in varying ratios and in different combinations. The organism readily acquired resistance and cross-resistance to neamine and neomycin C to a high degree but only slightly to neomycin B. The diaminohexose portion of neomycin B is responsible for the specific growth-inhibitory effect of this antibiotic on these 2 bacteria.Keywords
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