NALOXONE DECREASES FOOD INTAKE IN OBESE HUMANS
- 1 July 1982
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 55 (1), 196-198
- https://doi.org/10.1210/jcem-55-1-196
Abstract
Food intake decreased with a 15 mg naloxone infusion in obese humans but not in lean controls or obese subjects given 2 mg. Glucose and insulin levels did not differ from control during naloxone infusion alone or with meal stimulation. Endogenous opiates may contribute to obesity in humans but probably not through changes in insulin secretion.This publication has 13 references indexed in Scilit:
- Naloxone, Adrenalectomy, and Steroid Replacement:Evidence against a Role for Circulating β-Endorphin in Food Intake*Endocrinology, 1981
- Mediation of Diurnal Fluctuations in Pain Sensitivity in the Rat by Food Intake Patterns: Reversal by NaloxoneScience, 1980
- EFFECT OF NALOXONE IN A PREVIOUSLY UNDESCRIBED HYPOTHALAMIC SYNDROMEThe Lancet, 1980
- Endocrine Effects of Naloxone-Induced Opiate Receptor Blockade *Journal of Clinical Endocrinology & Metabolism, 1980
- Disparate effects of enkephalin and morphine upon insulin and glucagon secretion by islet cell culturesDiabetes, 1980
- β-ENDORPHIN IN THE HUMAN PANCREASJournal of Clinical Endocrinology & Metabolism, 1979
- Suppression of food intake and body weight gain by naloxone in ratsLife Sciences, 1979
- β-Endorphin Is Associated with Overeating in Genetically Obese Mice ( ob / ob ) and Rats ( fa / fa )Science, 1978
- Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studiesEuropean Journal of Pharmacology, 1978
- Stimulation of food intake by muscimol and beta endorphinNeuropharmacology, 1977