Aging and sister chromatid exchange
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 27 (2-3), 82-87
- https://doi.org/10.1159/000131469
Abstract
Induction of sister chromatid exchanges (SCE) was examined as a function of post-embryonic development in C57BL/6J mice and Wistar rat bone marrow cells. At low concentrations of three different mutagens, cyclophosphamide, mitomycin C, and doxorubicin, induced SCE levels were not altered with post-embryonic development. However, at higher mutagen concentrations, SCE induction was significantly reduced in growing (3- to 8-week-old) animals when compared to mature (7- to 9-month-old) animals. Studies of 1- to 8-month-old mice at these high doses revealed that mutagen-induced SCE frequencies increase gradually during this period. These results suggest that with post-embryonic development, changes occur in cellular response to mutagen-induced DNA damage.Keywords
This publication has 2 references indexed in Scilit:
- Spontaneous and mitomycin-C induced sister-chromatid exchangesMutation Research, 1979
- Reduced frequencies of Mitomycin-C induced sister chromatid exchanges in AKR MiceHuman Genetics, 1978