Effect of Dibenamine on Renal Hypertension in Rats.

Abstract

A total of 22 rats made hypertensive by bilateral compression of renal parenchyma and 6 controls were given daily oral doses of 100 mg./ kg. of Dibenamine for 3 or 10 days, and their blood pressure was measured by tail plethysmograph at frequent intervals during and after the admn. of the drug. Dibenamine caused a reduction of blood pressure in both control and renal hypertensive animals; the effect was more prolonged and pronounced in the latter. Blood pressure usually returned to pretreatment levels 3 to 4 days after last dosage. The drug caused a sustained lowering of blood pressure in 40% of rats hypertensive for over 2 months and in 75% of rats hypertensive for less than 2 months. The effect of Dibenamine was probably due to its adrenergic blocking action, since adrenergically inactive N,N-dibenzyl-ethanolamine produced no lowering of blood pressure. There is no greater neurogenic factor involved in late than in early renal hypertension.