Effect of Meprobamate on the Multiplication of Brucella abortus in Monocytes
- 8 December 1961
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 134 (3493), 1882-1883
- https://doi.org/10.1126/science.134.3493.1882
Abstract
Peritoneal mononuclear phagocytes (monocytes) obtained from guinea pigs that had been treated with meprobamate do not support, in vitro, the intracellular growth of smooth Brucella abortus that is characteristic of monocytes from untreated animals. This modification of intracellular events appears to be due to an indirect action of the drug, since meprobamate does not produce any effects following direct exposure of monocytes or bacteria to the drug in vitro. Furthermore, the brucellacidal activity of serum from animals exposed to meprobamate is not increased. An interaction between monocytes and a component in the serum of animals exposed to meprobamate is required for the altered intracellular events.Keywords
This publication has 5 references indexed in Scilit:
- Depressing Activity of Meprobamate on the Reticulo-Endothelial SystemNature, 1960
- Continuous Grouth of Brucella abortus in Mononuclear Phagocytes of Rats and Guinea Pigs.Experimental Biology and Medicine, 1959
- The action of tranquilizing drugs on brain metabolismCellular and Molecular Life Sciences, 1958
- Interactions Between Mononuclear Phagocytes and Brucella abortus Strains of Different Virulence.Experimental Biology and Medicine, 1958
- Intracellular Multiplication of Brucella abortus in Normal and Immune Mononuclear Phagocytes.Experimental Biology and Medicine, 1957