Models for high cell density bioreactors must consider biomass volume fraction: Cell recycle example
- 20 June 1987
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 29 (9), 1075-1080
- https://doi.org/10.1002/bit.260290906
Abstract
Intrinsic models, which take into account biomass volume fraction, must be formulated for adequate simulation of high-biomass-density fermentations with cell recycle. Through comparison of corresponding intrinsic and non-intrinsic models in dimensionless form, constraints for non-intrinsic model usage in terms of biokinetic and fermenter operating parameters can be identified a priori. Analysis of a simple product-inhibition model indicates that the non-intrinsic approach is suitable only when the attainable biomass volume fraction in the fermentation broth is less than about 0.10. Inappropriate application of a non-intrinsic model can lead to gross errors in calculated substrate and product concentrations, substrate conversion, and volumetric productivity.This publication has 9 references indexed in Scilit:
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