Insulin Secretion Following Carbutamide Injections in Normal Dogs.

Abstract

The mechanism of the hypoglycemic action of carbutamide in normal dogs was studied by means of pancreatic-femoral and mesenteric-femoral cross-circulation experiments. Results of these acute experiments suggest that: (1) carbutamide hypoglycemia is accompanied by the secretion of insulin; (2) carbutamide does not cause degranulation or other significant changes in the appearance of pancreatic A and B cells; (3) the clearance of carbutamide from the blood is relatively slow; (4) some dogs are refractory to the hypoglycemic action of carbutamide in doses of 50 mg/kg intravenous. Results are consistent with the hypothesis that insulin secretion is one of the results of carbutamide action.