Effects of local immunization with Streptococcus mutans on induction of salivary immunoglobulin A antibody and experimental dental caries in rats.
- 1 June 1974
- journal article
- Vol. 9 (6), 1079-91
Abstract
The effect of local immunization with Streptococcus mutans on dental caries in conventional and gnotobiotic rats was studied. Injection of these animals with S. mutans strain 6715 incorporated into complete Freund adjuvant consistently resulted in the presence of antibody in saliva directed to this organism. This antibody was primarily of the immunoglobulin A class as demonstrated by specific antiglobulin augmentation and gel filtration of antibody activity. Serum antibody was also present. Five experiments have been completed in conventional rats and two in gnotobiotic animals. The immunized group of animals always had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. The numbers of lesions were also always lower in the immunized animals, suggesting a possible interference with the formation of new lesions in immunized animals. The reductions in dental caries and lesions were greater on smooth surfaces than on occlusal surfaces. which might be explained as interference with adherence phenomena demonstrated by S. mutans. It is proposed that salivary immunoglobulin A antibody may be viewed as an ecological determinant in the oral cavity by affecting oral microorganisms and possibly their by-products.This publication has 59 references indexed in Scilit:
- Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen DisposalScience, 1972
- Acid Production from Glucose and Sucrose by Growing Cultures of Caries-Conducive StreptococciJournal of Dental Research, 1972
- Immunization with Dextransucrases and Glycosidic HydrolasesJournal of Dental Research, 1972
- Induction and properties of rabbit secretory γA antibody directed to group a streptococcal carbohydrateImmunochemistry, 1971
- CELL-MEDIATED IMMUNITY AND ANTIBODY RESPONSES IN THE RESPIRATORY TRACT AFTER LOCAL AND SYSTEMIC IMMUNIZATIONThe Journal of Experimental Medicine, 1971
- Serum and secretory immunoglobulins of the ratImmunochemistry, 1970
- Secretory γA Antibodies induced by Local ImmunizationNature, 1969
- QUANTITATIVE STUDIES OF THE IMMUNOGLOBULIN SEQUENCE IN THE RESPONSE OF THE RABBIT TO A SOMATIC ANTIGENThe Journal of Experimental Medicine, 1966
- CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONSThe Journal of Experimental Medicine, 1965
- Gamma-Globulins: Quantitative Relationships in Human Serum and Nonvascular FluidsScience, 1963